Hollow mesoporous silica nanoparticles functionalized with Pluronic for controlled drug release
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Keywords:
Drug delivery system, doxorubicin, fluronic, hollow mesoporous silica nanoparticles, thermosensitivity
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Abstract
In recent years, innovative drug-delivery systems have been considered one of the most crucial techniques for enhancing cancer treatment. In this study, F127, a thermal-sensitive polymer, was utilized to conjugate to the surface of HMSN, and subsequently, the carriers were loaded with Dox. The obtained product was characterized by a series of experiments, including TEM, FT-IR, TGA, XRD, and zeta potential. The HMSN-F127 carrier system was successfully synthesized with a size of 152.9 ± 0.9 nm. Furthermore, the SEM results revealed that the pores were located within the material. The zeta potential was determined to be -4.03 ± 0.15 mV, with a corresponding surface area of 168.4 m2/g. The efficiency and drug loading capacity of HMSN-F127 were found to be higher than those of naked HMSN with DLE and DLC values of 72.08 ± 0.09 % and 11.09 ± 0.01 %, respectively. In particular, Dox was well controlled by HMSN-F127. At concentrations ranging from 0 - 250 μg/ml, HMSN-F127 was not toxic to HCC J5 cells. The findings demonstrate that the HMSN-F127 system provides an effective platform for enhancing drug loading and achieving controlled drug release, thereby highlighting its potential for improved anticancer drug delivery and future development of stimuli-responsive nanocarriers.
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Nguyen, T. N. T., & Nguyen Thi, N. H. (2026). Hollow mesoporous silica nanoparticles functionalized with Pluronic for controlled drug release. Communications in Science and Technology, 11(1), 9–17. https://doi.org/10.21924/cst.11.1.2026.1861
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References
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2. Wu, S., X. Huang, and X. Du, pH-and redox-triggered synergistic controlled release of a ZnO-gated hollow mesoporous silica drug delivery system, Journal of Materials Chemistry B. 3 (2015) 1426-1432.
3. Cotí, K.K., et al., Mechanised nanoparticles for drug delivery, Nanoscale. 1 (2009) 16-39.
4. Yang, L. and P. Alexandridis, Physicochemical aspects of drug delivery and release from polymer-based colloids, Current opinion in colloid & interface science. 5 (2000). 5(1-2) 132-143.
5. Russo, E. and C. Villa, Poloxamer Hydrogels for Biomedical Applications, Pharmaceutics. 11(2019) 671.
6. Ruel-Gariepy, E. and J.-C. Leroux, In situ-forming hydrogels—review of temperature-sensitive systems, European Journal of Pharmaceutics and Biopharmaceutics. 58 (2004) 409-426.
7. Teotia, A., H. Sami, and A. Kumar, Thermo-responsive polymers: structure and design of smart materials, in Switchable and responsive surfaces and materials for biomedical applications. (2015) 3-43.
8. Zhang, W., et al., Synthesis and characterization of thermally responsive pluronic F127− chitosan nanocapsules for controlled release and intracellular delivery of small molecules, ACS nano. 4 (2010) 6747-6759.
9. Zeng, Z., et al., Facile fabrication of thermally responsive Pluronic F127-based nanocapsules for controlled release of doxorubicin hydrochloride, Colloid and Polymer Science. 292 (2014) 1521-1530.
10. Nguyen, T.T.C., et al., Highly lipophilic pluronics-conjugated polyamidoamine dendrimer nanocarriers as potential delivery system for hydrophobic drugs, Materials Science and Engineering: C. 70 (2017) 992-999.
11. Kim, J.D., et al., Thermo-responsive human α-elastin self-assembled nanoparticles for protein delivery, Colloids and Surfaces B: Biointerfaces. 149 (2017) 122-129.
12. Zhao, D., et al., Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores, Science. 279 (1998) 548-552.
13. Liu, Z., J. Ding, and J.J.N.J.o.C. Xue, A new family of biocompatible and stable magnetic nanoparticles: silica cross-linked pluronic F127 micelles loaded with iron oxides, New Journal of Chemistry. 33 (2009) 88-92.
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15. Tacar, O., P. Sriamornsak, and C.R. Dass, Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems, Journal of pharmacy and pharmacology. 65 (2013) 157-170.
16. Mobaraki, M., et al., Molecular mechanisms of cardiotoxicity: a review on major side-effect of doxorubicin, Indian Journal of Pharmaceutical Sciences. 79 (2017) 335-344.
17. Nguyen-Thi, N.-T., et al., The engineering of porous silica and hollow silica nanoparticles to enhance drug-loading capacity, Processes. 7 (2019) 805.
18. Nguyen, T.N.T., et al., Aminated hollow mesoporous silica nanoparticles as an enhanced loading and sustained releasing carrier for doxorubicin delivery, Microporous and Mesoporous Materials. 309 (2020) 110543.
19. Liu, J., et al., Hollow mesoporous silica nanoparticles facilitated drug delivery via cascade pH stimuli in tumor microenvironment for tumor therapy, Biomaterials. 83 (2016) 51-65.
20. Chen, Y., et al., Hollow/rattle-type mesoporous nanostructures by a structural difference-based selective etching strategy, ACS nano. 4 (2009) 529-539.
21. Slowing, I.I., et al., Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers, Advanced drug delivery reviews. 60 (2008) 1278-1288.
22. Carbone, C., et al., Adsorption of Mixed Dispersions of Silica Nanoparticles and an Amphiphilic Triblock Copolymer at the Water–Vapor Interface, Applied Sciences. 13 (2023) 10093.
23. Peer, D., et al., Nanocarriers as an emerging platform for cancer therapy, Nano-enabled medical applications. (2020) 61-91.
24. Nguyen, N.T., et al., Development and Characterization of Folic Acid‐Decorated Fucoidan‐Poloxamer 407 Self‐Assembled Nanogels Co‐Loading Curcumin and Paclitaxel for Synergistically Enhanced Chemotherapeutic Efficacy, Journal of Polymer Science. 63 (2025) 2405-2421.
25. Nguyen, N.T., et al., Efficient and controllable co-delivery of paclitaxel and curcumin from fucoidan-pluronic F127 nanogel for synergistic breast cancer treatment, Macromolecular. 32 (2024) 427-442.
26. Ly, H.Q., et al., Optimization of the poloxamer 407-conjugated gelatin to synthesize pH-sensitive nanocarriers for controlled paclitaxel delivery, Journal of Polymer Research 32 (2025) 38.
27. Nguyen, T.N.T., et al., Surface PEGylation of hollow mesoporous silica nanoparticles via aminated intermediate, Progress in Natural Science: Materials International. 29 (2019) 612-616.
28. Peer, D., et al., Nanocarriers as an emerging platform for cancer therapy, Nature nanotechnology. 2 (2007) 751-760.
29. Davis, M.E., Z. Chen, and D.M. Shin, Nanoparticle therapeutics: an emerging treatment modality for cancer, Nature reviews Drug discoveryjournals. 7 (2008) 771-782.
30. Cortés, H., et al., Non-ionic surfactants for stabilization of polymeric nanoparticles for biomedical uses, Materials. 14 (2021) 3197.
31. Sing, K.S., Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (Recommendations 1984), Pure and applied chemistry. 57 (1985) 603-619.
32. Xing, L., et al., Coordination polymer coated mesoporous silica nanoparticles for pH-responsive drug release, Advanced Materials (Deerfileld Beach, Fla.). 24 (2012) 6433-6437.
33. Shen, S., et al., High drug-loading nanomedicines: progress, current status, and prospects, International journal of nanomedicine. 12 (2017) 4085.
34. Nguyen-Thi, N.-T., et al., The engineering of porous silica and hollow silica nanoparticles to enhance drug-loading capacity, Processes. 7 (2019) 805.
35. Day, C.M., et al., Functionalized mesoporous silica nanoparticles as delivery systems for doxorubicin: drug loading and release, Applied Sciences. 11 (2021) 6121.
36. Guo, L., et al., A comprehensive study of drug loading in hollow mesoporous silica nanoparticles: Impacting factors and loading efficiency, Nanomaterials. 11 (2021) 1293.